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Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased TET2 mRNA expression (n=20 donors, *p<0.05). ( B ) DNMT1 mRNA expression was not significantly altered by dopamine treatment (n=21 donors). ( C ) <t>DNMT3A</t> mRNA expression was not significantly altered by dopamine treatment(n=18 donors). ( D ) DNMT3B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased TET2 mRNA expression (n=20 donors, *p<0.05). ( B ) DNMT1 mRNA expression was not significantly altered by dopamine treatment (n=21 donors). ( C ) <t>DNMT3A</t> mRNA expression was not significantly altered by dopamine treatment(n=18 donors). ( D ) DNMT3B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased TET2 mRNA expression (n=20 donors, *p<0.05). ( B ) DNMT1 mRNA expression was not significantly altered by dopamine treatment (n=21 donors). ( C ) <t>DNMT3A</t> mRNA expression was not significantly altered by dopamine treatment(n=18 donors). ( D ) DNMT3B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased TET2 mRNA expression (n=20 donors, *p<0.05). ( B ) DNMT1 mRNA expression was not significantly altered by dopamine treatment (n=21 donors). ( C ) DNMT3A mRNA expression was not significantly altered by dopamine treatment(n=18 donors). ( D ) DNMT3B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).

Journal: bioRxiv

Article Title: Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

doi: 10.64898/2026.01.21.700899

Figure Lengend Snippet: Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased TET2 mRNA expression (n=20 donors, *p<0.05). ( B ) DNMT1 mRNA expression was not significantly altered by dopamine treatment (n=21 donors). ( C ) DNMT3A mRNA expression was not significantly altered by dopamine treatment(n=18 donors). ( D ) DNMT3B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).

Article Snippet: TaqMan Fast Universal Master Mix, and PCR assay probes for DRD1-5 (Hs00265245_s1, Hs00241436_m1, Hs00364455_m1, Hs00609526_m1, Hs00361234_s1), IL1B (Hs01555410_m1), DNMT1 (Hs00945875_m1), DNMT3A (Hs01027166_m1), DNMT3B (Hs00171876_m1), TET2 (Hs00325999_m1), HDAC2 (Hs00231032_m1), HDAC6 (Hs00997427_m1), KDM6B (Hs00996325_g1), KAT2A (Hs00904943_gH), and 18S (4319413E) genes were purchased from Applied Biosystems.

Techniques: Derivative Assay, Gene Expression, Expressing

Data from were stratified by donor sex and age to assess potential sources of inter-donor variability. ( A ) Dopamine significantly increased TET2 mRNA expression in hMDM from female donors but not male donors (n=10 per group, *p<0.05). ( B ) Dopamine did not significantly alter DNMT1 gene expression in either male (n=10) or female (n=11) hMDM. ( C ) Dopamine treatment showed a decreasing trend in DNMT3A expression in male hMDM (n=9; p=0.0712) and a non-significant increase in female hMDM (n=9). ( D ) Dopamine treatment showed a decreasing trend in DNMT3B expression in male hMDM (n=11; p=0.0823) and a non-significant increase in female hMDM (n=6). ( E ) Dopamine treatment showed an increasing trend in TET2 gene expression in donors under 40 years of age (n=10, p=0.0645), but not donors aged 40 years or older (n=10). ( F-H ) No age-associated differences were observed for dopamine-induced changes in (F) DNMT1, (G) DNMT3A, or (H) DNMT3B expression.

Journal: bioRxiv

Article Title: Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

doi: 10.64898/2026.01.21.700899

Figure Lengend Snippet: Data from were stratified by donor sex and age to assess potential sources of inter-donor variability. ( A ) Dopamine significantly increased TET2 mRNA expression in hMDM from female donors but not male donors (n=10 per group, *p<0.05). ( B ) Dopamine did not significantly alter DNMT1 gene expression in either male (n=10) or female (n=11) hMDM. ( C ) Dopamine treatment showed a decreasing trend in DNMT3A expression in male hMDM (n=9; p=0.0712) and a non-significant increase in female hMDM (n=9). ( D ) Dopamine treatment showed a decreasing trend in DNMT3B expression in male hMDM (n=11; p=0.0823) and a non-significant increase in female hMDM (n=6). ( E ) Dopamine treatment showed an increasing trend in TET2 gene expression in donors under 40 years of age (n=10, p=0.0645), but not donors aged 40 years or older (n=10). ( F-H ) No age-associated differences were observed for dopamine-induced changes in (F) DNMT1, (G) DNMT3A, or (H) DNMT3B expression.

Article Snippet: TaqMan Fast Universal Master Mix, and PCR assay probes for DRD1-5 (Hs00265245_s1, Hs00241436_m1, Hs00364455_m1, Hs00609526_m1, Hs00361234_s1), IL1B (Hs01555410_m1), DNMT1 (Hs00945875_m1), DNMT3A (Hs01027166_m1), DNMT3B (Hs00171876_m1), TET2 (Hs00325999_m1), HDAC2 (Hs00231032_m1), HDAC6 (Hs00997427_m1), KDM6B (Hs00996325_g1), KAT2A (Hs00904943_gH), and 18S (4319413E) genes were purchased from Applied Biosystems.

Techniques: Expressing, Gene Expression

Donors from were combined with an independent archival cohort to assess correlations between dopamine receptor expression and epigenetic enzyme expression by qPCR. DRD1 expression was significantly correlated with ( A ) TET2 (n=32, *p<0.05), ( B ) DNMT1 (n=27, **p<0.01), and ( C ) DNMT3A (n=30, ***p<0.001), but not with ( D ) DNMT3B expression (n=27, p=0.0532). DRD5 expression was not correlated with ( E ) TET2 (n=32, p=0.0642) or ( H ) DNMT3B (n=27), but was significantly correlated with ( F ) DNMT1 (n=29, *p<0.05) and ( G ) DNMT3A (n=30, *p<0.05).

Journal: bioRxiv

Article Title: Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

doi: 10.64898/2026.01.21.700899

Figure Lengend Snippet: Donors from were combined with an independent archival cohort to assess correlations between dopamine receptor expression and epigenetic enzyme expression by qPCR. DRD1 expression was significantly correlated with ( A ) TET2 (n=32, *p<0.05), ( B ) DNMT1 (n=27, **p<0.01), and ( C ) DNMT3A (n=30, ***p<0.001), but not with ( D ) DNMT3B expression (n=27, p=0.0532). DRD5 expression was not correlated with ( E ) TET2 (n=32, p=0.0642) or ( H ) DNMT3B (n=27), but was significantly correlated with ( F ) DNMT1 (n=29, *p<0.05) and ( G ) DNMT3A (n=30, *p<0.05).

Article Snippet: TaqMan Fast Universal Master Mix, and PCR assay probes for DRD1-5 (Hs00265245_s1, Hs00241436_m1, Hs00364455_m1, Hs00609526_m1, Hs00361234_s1), IL1B (Hs01555410_m1), DNMT1 (Hs00945875_m1), DNMT3A (Hs01027166_m1), DNMT3B (Hs00171876_m1), TET2 (Hs00325999_m1), HDAC2 (Hs00231032_m1), HDAC6 (Hs00997427_m1), KDM6B (Hs00996325_g1), KAT2A (Hs00904943_gH), and 18S (4319413E) genes were purchased from Applied Biosystems.

Techniques: Expressing